1. In vitro modeling studies for the technical development and feasibility
assessment of endosaccular occlusion of intracranial aneurysms using
a nonadhesive liquid co-polymer (ethylene vinyl alcohol), and microballoon
assisted ("neck plastic") techniques.
2. In vivo preclinical studies to assess feasibility and efficacy of
endosaccular obliteration of aneurysms using a nonadhesive liquid co-polymer
(ethylene vinyl alcohol), and microballoon assisted techniques in a
swine model
3. Development of a fluid mechanics laboratory for studying hemodynamic
pathophysiology of intracranial aneurysms
4. Preclinical development and evaluation of ethylene vinyl alcohol
copolymer for direct puncture tumor embolization using the rabbit hypervascular
neoplasm model
5. Engineering modeling of polymerization and binding mechanics of
cyanoacrylates
6. Development of a canine model of human cerebrovascular geometry
for standardized evaluations of the technical performance characteristics
of various microcatheter PTCA and stent devices under consideration
for the treatment of human cerebrovascular occlusive disease
7. In vivo studies elucidating the role(s) of angiogenesis in the pathoetiology
of arteriovenous shunting malformations of the central nervous system
using previously developed animal models
8. Phase I/II multicenter randomized clinical trial evaluating the
safety and efficacy of transarterial therapeutic embolization of hypervascular
tumors using ethylene vinyl alcohol copolymer compared to polyvinyl
alcohol suspensions
9. NINDS Phase III multicenter randomized clinical trial comparing
the safety and efficacy of carotid PTA/stenting with open endarterectomy.